Angela Santa Fe was named the 10th head women's basketball coach in program history in August of 2013. After two years under Julie Plant, Santa Fe helped lead the Pride to a pair of NECC Tournament bids as well as the 2012-13 NECC Championship and an appearance in the NCAA Tournament.

In her first season at the helm of the program in 2013-14, Santa Fe led the Pride to a 23-5 mark and a second-straight NECC Championship and NCAA Tournament appearance. Regis extended its regular-season NECC winning-streak to 54 games as well. 

Santa Fe helped lead the Pride to an unblemished 36-0 mark in its first two years in the NECC. While as an assistant, the Pride also made its first NCAA Tournament appearance since the 1995-1996 season. She served as the women's basketball program's recruiting coordinator and also coordinated all team travel, film exchange, fundraising and community service. On the floor, Santa Fe was responsible for all post play development as well as scouting reports and practice plans.

Prior to Regis, Santa Fe spent a year as an assistant on the University of Southern Maine women's basketball team after graduating from USM in 2011. She was a three-year member of the program, helping lead the Huskies to three-straight NCAA Tournament appearances including an appearance in the 2006 NCAA Championship Game and a Sweet 16 bid in 2007. She scored 551 points (6.8 ppg) and grabbed 262 rebounds (3.2 rpg) in her three years in Gorham, Maine.

An adept shooter, Santa Fe finished her career with an outstanding 47.3 percent (205-433) mark from the field and 551 points in 84 career games. She served as one of the team's captains in 2007-2008.